Specificity in IDR-IDR Interactions
Interrogating how non-random amino acid sequence patterns within the intrinsically disordered regions (IDRs) of chromatin-associated proteins engage in specific intermolecular interactions, as well as how these interactions are altered in neurodegenerative disorders and cancer.
A Chemical Atlas of the Nucleus
Developing and deploying quantitative microscopy tools to map the absolute concentrations of metabolites and ions across distinct nuclear bodies and the surrounding nucleoplasm.
Macromolecular Assembly in Nuclear Bodies
Investigating how the composition of intrinsically disordered proteins and local solution properties of the nucleolus provide chemical driving forces for ribosome biogenesis.
Physicochemical Regulation of Enzymes
Determining how local physicochemical properties, including pH, modulate IDR interaction potentials and tune the activity of resident enzymes in nuclear bodies.
